{"id":19,"date":"2022-07-15T10:32:01","date_gmt":"2022-07-15T09:32:01","guid":{"rendered":"https:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/?page_id=19"},"modified":"2024-04-08T15:50:07","modified_gmt":"2024-04-08T14:50:07","slug":"projects-and-opportunities","status":"publish","type":"page","link":"https:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/projects-and-opportunities\/","title":{"rendered":"Projects and opportunities"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Development and establishment of physiologically relevant <em>in vitro<\/em> models<\/h2>\n\n\n\n<p>Using a range of <em>in vitro<\/em> blood-brain barrier (BBB) models, we aim to understand the detailed cellular and molecular mechanisms of BBB disruption in neurological and cardiovascular diseases.We are keen to collaborate with pharmaceutical industry partners to test brain penetration of selected neuroprotective drugs across the BBB using these model systems.<\/p>\n\n\n\n<p>Contact Dr Patabendige for contract research opportunities to test CNS penetration of drugs.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Replacement of animal models for studying the blood-brain barrier<\/h2>\n\n\n\n<p>We\u2019re committed to the 3Rs and committed to develop non-animal technologies to study BBB disruption in neurological diseases.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Understanding the pathophysiology of ischaemic stroke and the role of cerebrospinal fluid dynamics<\/h2>\n\n\n\n<p class=\"has-black-color has-text-color\">We are unravelling the mechanisms involved in the pathophysiology of impaired brain fluid homeostasis in neurological diseases such as stroke and brain trauma. Disruption of brain fluid dynamics can be life threatening, as this leads to an elevated intracranial pressure (ICP). We have demonstrated that changes in cerebrospinal fluid (CSF) volume can lead to ICP elevation in ischaemic stroke in preclinical studies. We are now exploring clinical translation and potential treatment strategies to reduce the ICP elevation in ischaemic stroke.&nbsp;<\/p>\n\n\n\n<div style=\"height:19px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<ul class=\"has-black-color has-text-color wp-block-list\">\n<li>For a comprehensive review on the blood-brain barrier (BBB) see <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0969996109002083?via%3Dihub\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0969996109002083?via%3Dihub<\/a><\/li>\n\n\n\n<li>For a discussion on the evidence for BBB disruption during atrial fibrillation see <a href=\"https:\/\/royalsocietypublishing.org\/doi\/10.1098\/rsob.200396\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/royalsocietypublishing.org\/doi\/10.1098\/rsob.200396<\/a><\/li>\n\n\n\n<li>To understand the impact of cerebrospinal fluid (CSF) dynamics on neurological diseases see <a href=\"https:\/\/fluidsbarrierscns.biomedcentral.com\/articles\/10.1186\/s12987-019-0129-6\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/fluidsbarrierscns.biomedcentral.com\/articles\/10.1186\/s12987-019-0129-6<\/a><\/li>\n<\/ul>\n\n\n\n<p><strong>Contact Dr Patabendige: <a href=\"mailto:Adjanie.Patabendige@edgehill.ac.uk\" target=\"_blank\" rel=\"noreferrer noopener\">Adjanie.Patabendige@edgehill.ac.uk<\/a><\/strong><\/p>\n\n\n\n<div style=\"height:19px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-black-color has-text-color has-background\" style=\"background-color:#dedede\">PhD students \u2013 projects on BBB\/CSF\/stroke\/Alzheimer\u2019s disease\/dementia\/atrial fibrillation<\/p>\n\n\n\n<p class=\"has-black-color has-text-color has-background\" style=\"background-color:#dedede\">Early career researchers and postdocs \u2013 inquire for support with studentship\/fellowship applications<\/p>\n\n\n\n<p class=\"has-black-color has-text-color has-background\" style=\"background-color:#dedede\">Undergraduate students \u2013 placements available<\/p>\n\n\n\n<div class=\"wp-block-media-text alignwide has-media-on-the-right is-stacked-on-mobile\" style=\"grid-template-columns:auto 60%\"><div class=\"wp-block-media-text__content\">\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-d0be8a7\" data-block-id=\"d0be8a7\"><p class=\"stk-block-text__text\"> <strong>We have state-of-the-art cell culture facilities within the Biology department and fully equipped laboratory suites with excellent technical support.<\/strong> <\/p><\/div>\n<\/div><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"572\" src=\"http:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/wp-content\/uploads\/sites\/349\/2022\/07\/labs-1024x572.png\" alt=\"\" class=\"wp-image-142 size-full\" srcset=\"https:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/wp-content\/uploads\/sites\/349\/2022\/07\/labs-1024x572.png 1024w, https:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/wp-content\/uploads\/sites\/349\/2022\/07\/labs-300x168.png 300w, https:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/wp-content\/uploads\/sites\/349\/2022\/07\/labs-768x429.png 768w, https:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/wp-content\/uploads\/sites\/349\/2022\/07\/labs-1536x858.png 1536w, https:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/wp-content\/uploads\/sites\/349\/2022\/07\/labs-2048x1144.png 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n\n<div style=\"height:45px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Development and establishment of physiologically relevant in vitro models Using a range of in vitro blood-brain barrier (BBB) models, we aim to understand the detailed cellular and molecular mechanisms of BBB disruption in neurological and cardiovascular diseases.We are keen to collaborate with pharmaceutical industry partners to test brain penetration of selected neuroprotective drugs across the [&hellip;]<\/p>\n","protected":false},"author":2059,"featured_media":0,"parent":0,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-19","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.5 - 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