{"id":85,"date":"2022-07-15T10:42:53","date_gmt":"2022-07-15T09:42:53","guid":{"rendered":"https:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/?page_id=85"},"modified":"2024-04-08T14:36:52","modified_gmt":"2024-04-08T13:36:52","slug":"about","status":"publish","type":"page","link":"https:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/","title":{"rendered":"About"},"content":{"rendered":"\n<figure class=\"wp-block-image aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"576\" src=\"http:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/wp-content\/uploads\/sites\/349\/2024\/04\/Brain-Barriers-logo-1024x576.jpg\" alt=\"Brain Barriers logo.\" class=\"wp-image-442\" style=\"width:586px;height:auto\" srcset=\"https:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/wp-content\/uploads\/sites\/349\/2024\/04\/Brain-Barriers-logo-1024x576.jpg 1024w, https:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/wp-content\/uploads\/sites\/349\/2024\/04\/Brain-Barriers-logo-300x169.jpg 300w, https:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/wp-content\/uploads\/sites\/349\/2024\/04\/Brain-Barriers-logo-768x432.jpg 768w, https:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/wp-content\/uploads\/sites\/349\/2024\/04\/Brain-Barriers-logo-1536x864.jpg 1536w, https:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/wp-content\/uploads\/sites\/349\/2024\/04\/Brain-Barriers-logo.jpg 1920w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>We are interested in understanding the physiology and pathophysiology of brain barriers and fluids. Normal functioning of brain barriers and fluids is vital for protection of the brain and maintaining homeostasis of the neuronal microenvironment. Often these defences are disrupted during neurological diseases such as stroke, Alzheimer\u2019s disease, brain tumours and brain infections. Furthermore, emerging evidence also point to barrier disruption during peripheral diseases such as atrial fibrillation.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"576\" src=\"http:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/wp-content\/uploads\/sites\/349\/2024\/04\/BBB-disruption-page-one-1024x576.jpg\" alt=\"Blood brain barrier (BBB) image.\" class=\"wp-image-444\" srcset=\"https:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/wp-content\/uploads\/sites\/349\/2024\/04\/BBB-disruption-page-one-1024x576.jpg 1024w, https:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/wp-content\/uploads\/sites\/349\/2024\/04\/BBB-disruption-page-one-300x169.jpg 300w, https:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/wp-content\/uploads\/sites\/349\/2024\/04\/BBB-disruption-page-one-768x432.jpg 768w, https:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/wp-content\/uploads\/sites\/349\/2024\/04\/BBB-disruption-page-one-1536x864.jpg 1536w, https:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/wp-content\/uploads\/sites\/349\/2024\/04\/BBB-disruption-page-one.jpg 1920w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\"><a href=\"https:\/\/doi.org\/10.1042\/BST20220830\">Blood-brain barrier (BBB) disruption<\/a> (Patabendige &amp; Janigro 2023)<\/figcaption><\/figure>\n\n\n\n<p>To investigate the detailed cellular and molecular mechanisms of brain barriers and fluids, we have developed a range of advanced <em>in vitro <\/em>models that can reliably mimic the <em>in vivo<\/em> pathophysiology.<\/p>\n\n\n\n<p>We are open to collaborations and sharing these model systems to better understand disease mechanisms.<\/p>\n\n\n\n<ul class=\"wp-block-social-links has-visible-labels is-style-logos-only is-layout-flex wp-block-social-links-is-layout-flex\"><li class=\"wp-social-link wp-social-link-twitter  wp-block-social-link\"><a href=\"https:\/\/twitter.com\/APatabendige\" class=\"wp-block-social-link-anchor\"><svg width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M22.23,5.924c-0.736,0.326-1.527,0.547-2.357,0.646c0.847-0.508,1.498-1.312,1.804-2.27 c-0.793,0.47-1.671,0.812-2.606,0.996C18.324,4.498,17.257,4,16.077,4c-2.266,0-4.103,1.837-4.103,4.103 c0,0.322,0.036,0.635,0.106,0.935C8.67,8.867,5.647,7.234,3.623,4.751C3.27,5.357,3.067,6.062,3.067,6.814 c0,1.424,0.724,2.679,1.825,3.415c-0.673-0.021-1.305-0.206-1.859-0.513c0,0.017,0,0.034,0,0.052c0,1.988,1.414,3.647,3.292,4.023 c-0.344,0.094-0.707,0.144-1.081,0.144c-0.264,0-0.521-0.026-0.772-0.074c0.522,1.63,2.038,2.816,3.833,2.85 c-1.404,1.1-3.174,1.756-5.096,1.756c-0.331,0-0.658-0.019-0.979-0.057c1.816,1.164,3.973,1.843,6.29,1.843 c7.547,0,11.675-6.252,11.675-11.675c0-0.178-0.004-0.355-0.012-0.531C20.985,7.47,21.68,6.747,22.23,5.924z\"><\/path><\/svg><span class=\"wp-block-social-link-label\">@APatabendige<\/span><\/a><\/li>\n\n<li class=\"wp-social-link wp-social-link-mail  wp-block-social-link\"><a href=\"mailto:A&#100;&#106;ani&#101;.&#080;at&#097;be&#110;d&#105;g&#101;&#064;e&#100;&#103;&#101;h&#105;ll.&#097;&#099;&#046;uk\" class=\"wp-block-social-link-anchor\"><svg width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M19,5H5c-1.1,0-2,.9-2,2v10c0,1.1.9,2,2,2h14c1.1,0,2-.9,2-2V7c0-1.1-.9-2-2-2zm.5,12c0,.3-.2.5-.5.5H5c-.3,0-.5-.2-.5-.5V9.8l7.5,5.6,7.5-5.6V17zm0-9.1L12,13.6,4.5,7.9V7c0-.3.2-.5.5-.5h14c.3,0,.5.2.5.5v.9z\"><\/path><\/svg><span class=\"wp-block-social-link-label\">Adjanie.Patabendige@edgehill.ac.uk<\/span><\/a><\/li>\n\n<li class=\"wp-social-link wp-social-link-twitter  wp-block-social-link\"><a href=\"https:\/\/twitter.com\/Brain_Barriers\" class=\"wp-block-social-link-anchor\"><svg width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M22.23,5.924c-0.736,0.326-1.527,0.547-2.357,0.646c0.847-0.508,1.498-1.312,1.804-2.27 c-0.793,0.47-1.671,0.812-2.606,0.996C18.324,4.498,17.257,4,16.077,4c-2.266,0-4.103,1.837-4.103,4.103 c0,0.322,0.036,0.635,0.106,0.935C8.67,8.867,5.647,7.234,3.623,4.751C3.27,5.357,3.067,6.062,3.067,6.814 c0,1.424,0.724,2.679,1.825,3.415c-0.673-0.021-1.305-0.206-1.859-0.513c0,0.017,0,0.034,0,0.052c0,1.988,1.414,3.647,3.292,4.023 c-0.344,0.094-0.707,0.144-1.081,0.144c-0.264,0-0.521-0.026-0.772-0.074c0.522,1.63,2.038,2.816,3.833,2.85 c-1.404,1.1-3.174,1.756-5.096,1.756c-0.331,0-0.658-0.019-0.979-0.057c1.816,1.164,3.973,1.843,6.29,1.843 c7.547,0,11.675-6.252,11.675-11.675c0-0.178-0.004-0.355-0.012-0.531C20.985,7.47,21.68,6.747,22.23,5.924z\"><\/path><\/svg><span class=\"wp-block-social-link-label\">@Brain_Barriers<\/span><\/a><\/li><\/ul>\n","protected":false},"excerpt":{"rendered":"<p>We are interested in understanding the physiology and pathophysiology of brain barriers and fluids. Normal functioning of brain barriers and fluids is vital for protection of the brain and maintaining homeostasis of the neuronal microenvironment. Often these defences are disrupted during neurological diseases such as stroke, Alzheimer\u2019s disease, brain tumours and brain infections. Furthermore, emerging [&hellip;]<\/p>\n","protected":false},"author":2059,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-85","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>About - Brain Barriers Research<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"About - Brain Barriers Research\" \/>\n<meta property=\"og:description\" content=\"We are interested in understanding the physiology and pathophysiology of brain barriers and fluids. Normal functioning of brain barriers and fluids is vital for protection of the brain and maintaining homeostasis of the neuronal microenvironment. Often these defences are disrupted during neurological diseases such as stroke, Alzheimer\u2019s disease, brain tumours and brain infections. Furthermore, emerging [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/\" \/>\n<meta property=\"og:site_name\" content=\"Brain Barriers Research\" \/>\n<meta property=\"article:modified_time\" content=\"2024-04-08T13:36:52+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/files\/2024\/04\/Brain-Barriers-logo-1024x576.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/\",\"url\":\"https:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/\",\"name\":\"About - Brain Barriers Research\",\"isPartOf\":{\"@id\":\"https:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/#primaryimage\"},\"thumbnailUrl\":\"http:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/wp-content\/uploads\/sites\/349\/2024\/04\/Brain-Barriers-logo-1024x576.jpg\",\"datePublished\":\"2022-07-15T09:42:53+00:00\",\"dateModified\":\"2024-04-08T13:36:52+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/#primaryimage\",\"url\":\"https:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/wp-content\/uploads\/sites\/349\/2024\/04\/Brain-Barriers-logo.jpg\",\"contentUrl\":\"https:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/wp-content\/uploads\/sites\/349\/2024\/04\/Brain-Barriers-logo.jpg\",\"width\":1920,\"height\":1080,\"caption\":\"Brain Barriers logo.\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"About\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/#website\",\"url\":\"https:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/\",\"name\":\"Brain Barriers Research\",\"description\":\"Just another Sites at Edge Hill University site\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-GB\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"About - Brain Barriers Research","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/sites.edgehill.ac.uk\/brainbarriers-research\/","og_locale":"en_GB","og_type":"article","og_title":"About - Brain Barriers Research","og_description":"We are interested in understanding the physiology and pathophysiology of brain barriers and fluids. 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