{"id":72,"date":"2022-05-17T15:28:36","date_gmt":"2022-05-17T14:28:36","guid":{"rendered":"https:\/\/sites.edgehill.ac.uk\/molecular-biology\/?page_id=72"},"modified":"2024-10-01T08:26:48","modified_gmt":"2024-10-01T07:26:48","slug":"publications","status":"publish","type":"page","link":"https:\/\/sites.edgehill.ac.uk\/molecular-biology\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\n

Selected publications<\/h2>\n\n\n\n

Aging retinal pigmented epithelium: omics-based insights into vision decline<\/p>\n\n\n\n

Matei IV and Paraoan L (2024)<\/p>\n\n\n\n

Aging (Albany NY)<\/em> 16(12):10201-10202. doi: 10.18632\/aging.205914.<\/p>\n\n\n\n

\n\n\n\n

Fucoxanthin diminishes oxidative stress damage in human placenta-derived mesenchymal stem cells through the PI3K\/Akt\/Nrf-2 pathway.<\/p>\n\n\n\n

Suwanmanee G, Tantrawatpan C, Kheolamai P, Paraoan L<\/strong>, Manochantr S. (2023)<\/p>\n\n\n\n

Sci Rep<\/em> (Nature Publishing) <\/em>13(1):22974. doi: 10.1038\/s41598-023-49751-5.<\/p>\n\n\n\n

View abstract on Pubmed link: https:\/\/pubmed.ncbi.nlm.nih.gov\/38151503\/<\/a><\/p>\n\n\n\n

\n\n\n\n

Carlsson E, Sharif U, Supharattanasitthi W and Paraoan L. <\/strong>(2023)<\/p>\n\n\n\n

Analysis of Wild Type and Variant B Cystatin C Interactome in Retinal Pigment Epithelium Cells Reveals Variant B Interacting Mitochondrial Proteins<\/p>\n\n\n\n

Cells<\/em> 12(5):713. doi: 10.3390\/cells12050713.<\/p>\n\n\n\n

View abstract on Pubmed link: https:\/\/pubmed.ncbi.nlm.nih.gov\/36899848\/<\/a><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n
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Dhirachaikulpanich D, Lagger C, Chatsirisupachai K, de Magalh\u00e3es JP, Paraoan L.<\/strong> (2022)<\/p>\n\n\n\n

Intercellular communication analysis of the human retinal pigment epithelial and choroidal cells predicts pathways associated with aging, cellular senescence and age-related macular degeneration.<\/p>\n\n\n\n

Front Aging Neurosci.<\/strong><\/em> 14:1016293. doi: 10.3389\/fnagi.2022.1016293<\/p>\n\n\n\n

View abstract on Pubmed link: https:\/\/pubmed.ncbi.nlm.nih.gov\/36408112\/<\/a><\/p>\n\n\n\n

\n\n\n\n

Saptarshi N, Porter LF, Paraoan L<\/strong>. (2022)<\/p>\n\n\n\n

PERK\/EIF2AK3 integrates endoplasmic reticulum stress-induced apoptosis, oxidative stress and autophagy responses in immortalised retinal pigment epithelial cells.<\/p>\n\n\n\n

Sci Rep.<\/strong><\/em> 12(1):13324. doi: 10.1038\/s41598-022-16909-6<\/p>\n\n\n\n

View abstract on Pubmed link: https:\/\/pubmed.ncbi.nlm.nih.gov\/35922637\/<\/a><\/p>\n\n\n\n

\"PERK
PERK downregulation in RPE cells impairs ER-stress induced apoptosis in a Bax\/Bcl-2-dependent manner.<\/figcaption><\/figure>\n\n\n\n
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Jantalika T, Manochantr S, Kheolamai P, Tantikanlayaporn D, Saijuntha W, Pinlaor S, Chairoungdua A, Paraoan L<\/strong>, Tantrawatpan C. (2022)<\/p>\n\n\n\n

Human chorion-derived mesenchymal stem cells suppress JAK2\/STAT3 signaling and induce apoptosis of cholangiocarcinoma cell lines.<\/p>\n\n\n\n

Sci Rep<\/em>. 12(1):11341. doi: 10.1038\/s41598-022-15298-0<\/p>\n\n\n\n

View abstract on Pubmed link: https:\/\/pubmed.ncbi.nlm.nih.gov\/35790790\/<\/a><\/p>\n\n\n\n

\n\n\n\n

Mahmud NM, Paraoan L<\/strong>, Khaliddin N, Kamalden TA. (2022)<\/p>\n\n\n\n

Thymoquinone in Ocular Neurodegeneration: Modulation of Pathological Mechanisms via Multiple Pathways.<\/p>\n\n\n\n

Front Cell Neurosci.<\/em> 16:786926. doi: 10.3389\/fncel.2022.786926. eCollection 2022.PMID: 35308121<\/p>\n\n\n\n

View abstract on Pubmed link: https:\/\/pubmed.ncbi.nlm.nih.gov\/35308121\/<\/a><\/p>\n\n\n\n

\n\n\n\n

Saptarshi N, Green D, Cree A, Lotery A, Paraoan L<\/strong>, Porter LF. (2021)<\/p>\n\n\n\n

Epigenetic Age Acceleration Is Not Associated with Age-Related Macular Degeneration.<\/p>\n\n\n\n

Int J Mol Sci.<\/em> 22(24):13457. doi: 10.3390\/ijms222413457.PMID: 34948253<\/p>\n\n\n\n

View abstract on Pubmed link: https:\/\/pubmed.ncbi.nlm.nih.gov\/34948253\/<\/a><\/p>\n\n\n\n

\n\n\n\n

Butler JM, Supharattanasitthi W, Yang YC, Paraoan L<\/strong>. (2021)<\/p>\n\n\n\n

RNA-seq analysis of ageing human retinal pigment epithelium: Unexpected up-regulation of visual cycle gene transcription.<\/p>\n\n\n\n

J Cell Mol Med.<\/em> 25(12):5572-5585. doi: 10.1111\/jcmm.16569. Epub 2021 May 1.PMID: 33934486<\/p>\n\n\n\n

View abstract on Pubmed link: https:\/\/pubmed.ncbi.nlm.nih.gov\/33934486\/<\/a><\/p>\n\n\n\n

\"RNA-seq
RNA-seq analysis of ageing human retinal pigment epithelium. Reactome pathway analysis identifies an unexpected set of visual cycle-related genes that have increased expression with increasing age. (Significantly positively correlated genes (SCG), and complexes which include a SCG, highlighted in green.)<\/figcaption><\/figure>\n\n\n\n
\n\n\n\n

Muangnoi C, Phumsuay R, Jongjitphisut N, Waikasikorn P, Sangsawat M, Rashatasakhon P, Paraoan L<\/strong>, Rojsitthisak P. (2021)<\/p>\n\n\n\n

Protective Effects of a Lutein Ester Prodrug, Lutein Diglutaric Acid, against H2O2-Induced Oxidative Stress in Human Retinal Pigment Epithelial Cells.<\/p>\n\n\n\n

Int J Mol Sci.<\/em> 22(9):4722. doi: 10.3390\/ijms22094722.PMID: 33946898<\/p>\n\n\n\n

View abstract on Pubmed link: https:\/\/pubmed.ncbi.nlm.nih.gov\/33946898\/<\/a><\/p>\n\n\n\n

\n\n\n\n

Chatsirisupachai K, Lesluyes T, Paraoan L<\/strong>, Van Loo P, de Magalh\u00e3es JP. (2021)<\/p>\n\n\n\n

An integrative analysis of the age-associated multi-omic landscape across cancers.<\/p>\n\n\n\n

Nat Commun.<\/em> 12(1):2345. doi: 10.1038\/s41467-021-22560-y.PMID: 33879792<\/p>\n\n\n\n

View abstract on Pubmed link: https:\/\/pubmed.ncbi.nlm.nih.gov\/33879792\/<\/a><\/p>\n\n\n\n

\n\n\n\n

Roberts O, Paraoan L. <\/strong><\/p>\n\n\n\n

PERP-ing into diverse mechanisms of cancer pathogenesis: Regulation and role of the p53\/p63 effector PERP.<\/p>\n\n\n\n

Biochim Biophys Acta Rev Cancer<\/em>. 2020 Aug;1874(1):188393. doi: 10.1016\/j.bbcan.2020.188393.<\/p>\n\n\n\n

View abstract on Pubmed link: https:\/\/pubmed.ncbi.nlm.nih.gov\/32679166<\/a>\/  <\/p>\n\n\n\n

\"Known
Known and hypothesised effects of downregulation of the apoptosis effector PERP in cancer cells.<\/figcaption><\/figure>\n\n\n\n
\n\n\n\n

Dhirachaikulpanich D, Li X, Porter LF, Paraoan L.<\/strong><\/p>\n\n\n\n

Integrated Microarray and RNAseq Transcriptomic Analysis of Retinal Pigment Epithelium\/Choroid in Age-Related Macular Degeneration.<\/p>\n\n\n\n

Front Cell Dev Biol<\/em>. 2020 Aug 21;8:808. doi: 10.3389\/fcell.2020.00808 <\/p>\n\n\n\n

View abstract on Pubmed link: https:\/\/pubmed.ncbi.nlm.nih.gov\/32984320<\/a>\/ <\/p>\n\n\n\n

\n\n\n\n

Paraoan L<\/strong>, Sharif U, Carlsson E, Supharattanasitthi W, Mahmud NM, Kamalden TA, Hiscott P, Jackson M, Grierson I.<\/p>\n\n\n\n

Secretory proteostasis of the retinal pigmented epithelium: Impairment links to age-related macular degeneration.<\/a><\/p>\n\n\n\n

Prog Retin Eye Res<\/em>. 2020 Apr 9:100859. doi: 10.1016\/j.preteyeres.2020.100859.<\/p>\n\n\n\n

View abstract on Pubmed link: https:\/\/pubmed.ncbi.nlm.nih.gov\/32278708\/<\/a><\/p>\n\n\n\n

\n\n\n\n

Carlsson E, Supharattanasitthi W, Jackson M & Paraoan L.<\/strong><\/p>\n\n\n\n

Increased Rate of Retinal Pigment Epithelial Cell Migration and Pro-Angiogenic Potential Ensuing From Reduced Cystatin C Expression<\/p>\n\n\n\n

Invest Ophthalmol Vis Sci<\/em>.<\/em> 2020 Feb 7;61(2):9. doi: 10.1167\/iovs.61.2.9.<\/p>\n\n\n\n

View abstract on Pubmed link:https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32049341<\/a> <\/p>\n\n\n\n

\n\n\n\n

McDonnell S.J., Spiller D.G., White M.R.H., Prior I. & Paraoan L.<\/strong><\/p>\n\n\n\n

ER stress-linked autophagy stabilizes apoptosis effector PERP and triggers its co-localization with SERCA2b at ER\u2013plasma membrane junctions<\/a><\/p>\n\n\n\n

Cell Death Discovery<\/em> (2019) 5:132; doi:10.1038\/s41420-019-0212-4<\/p>\n\n\n\n

View abstract on Pubmed link: https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31508245<\/a><\/p>\n\n\n\n

\"ER<\/figure>\n\n\n\n

ER stress-modulated increased interaction of PERP and SERCA2b at ER-plasma membrane points of contact<\/strong><\/p>\n\n\n\n

\n\n\n\n

Muangnoi C, Ratnatilaka Na Bhuket P, Jithavech P, Supasena W, Paraoan L<\/strong>, Patumraj S, Rojsitthisak P.<\/p>\n\n\n\n

Sci Rep. 2019 Aug 12;9(1):11718. doi: 10.1038\/s41598-019-48124-1.<\/p>\n\n\n\n

Curcumin diethyl disuccinate, a prodrug of curcumin, enhances anti-proliferative effect of curcumin against HepG2 cells via apoptosis induction.<\/a><\/p>\n\n\n\n

\n\n\n\n

Supharattanasitthi W, Carlsson E, Sharif U, Paraoan L<\/strong>.<\/p>\n\n\n\n

CRISPR\/Cas9-mediated one step bi-allelic change of genomic DNA in iPSCs and human RPE cells in vitro<\/em> with dual antibiotic selection.<\/p>\n\n\n\n

Sci Rep 2019 9:174. doi: 10.1038\/s41598-018-36740-2.<\/p>\n\n\n\n

View abstract on Pubmed link: https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30655567<\/a><\/p>\n\n\n\n

\"Stem<\/h2>\n\n\n\n

Pluripotent stem cells following first gene editing of AMD risk factor (Sci Rep 2019 9:174)<\/strong><\/p>\n\n\n\n

\n\n\n\n

Muangnoi C, Sharif U, Ratnatilaka Na Bhuket P, Rojsitthisak P, Paraoan L.<\/strong><\/p>\n\n\n\n

Protective Effects of Curcumin Ester Prodrug, Curcumin Diethyl Disuccinate against H2O2-Induced Oxidative Stress in Human Retinal Pigment Epithelial Cells: Potential Therapeutic Avenues for Age-Related Macular Degeneration.<\/a><\/p>\n\n\n\n

Int J Mol Sci. 2019 Jul 9;20(13). pii: E3367. doi: 10.3390\/ijms20133367.<\/p>\n\n\n\n

View abstract on Pubmed link:https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31323999<\/a> <\/p>\n\n\n\n

\n\n\n\n

Porter LF, Saptarshi N, Fang Y, Rathi S, den Hollander AI, de Jong EK, Clark SJ, Bishop PN, Olsen TW, Liloglou T, Chavali VRM, Paraoan L<\/strong>.<\/p>\n\n\n\n

Whole-genome methylation profiling of the retinal pigment epithelium of individuals with age-related macular degeneration reveals differential methylation of the SKI, GTF2H4, and TNXB genes.<\/p>\n\n\n\n

Clin Epigenetics. 2019 11(1):6. doi: 10.1186\/s13148-019-0608-2.<\/p>\n\n\n\n

View abstract on Pubmed link: https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30642396<\/a><\/p>\n\n\n\n

\n\n\n\n

Sharif U, Mahmud NM, Kay P, Yang YC, Harding SP, Grierson I, Kamalden TA, Jackson MJ, Paraoan L<\/strong>.<\/p>\n\n\n\n

Advanced glycation end products-related modulation of cathepsin L and NF-\u03baB signalling effectors in retinal pigment epithelium lead to augmented response to TNF\u03b1.<\/p>\n\n\n\n

Epub 2018 Oct 19. J Cell Mol Med. 2019 23(1):405-416. doi: 10.1111\/jcmm.13944. Epub 2018 Oct 19.<\/p>\n\n\n\n

View abstract on Pubmed link: https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30338926<\/a><\/p>\n\n\n\n

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Butler JM, Hall N, Narendran N, Yang YC, Paraoan L.<\/strong><\/p>\n\n\n\n

Identification of candidate protective variants for common diseases and evaluation of their protective potential.<\/p>\n\n\n\n

BMC Genomics. 2017 18(1):575. doi: 10.1186\/s12864-017-3964-3. <\/p>\n\n\n\n

View abstract on Pubmed<\/a><\/p>\n\n\n\n

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Awais, Spiller, White, Paraoan<\/strong> L<\/strong>. p63 is required beside p53 for PERP-mediated apoptosis in uveal melanoma. Br J Cancer. 2016 Sep 1. PMID: 27584665. View Abstract on PubMed<\/a><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n
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Sant’Anna R, Navarro S, Ventura S, Paraoan L<\/strong>, Foguel D. <\/p>\n\n\n\n

Amyloid properties of the leader peptide of variant B cystatin C: implications for Alzheimer and Macular Degeneration. FEBS Lett. 2016 Feb 10. PMID: 26865059 View abstract on PubMed<\/a><\/p>\n\n\n\n

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Butler JM, Sharif U, Ali M, McKibbin M, Thompson JP, Gale R, Yang YC, Inglehearn C, Paraoan L<\/strong>.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

A missense variant in CST3 exerts a recessive effect on susceptibility to age-related macular degeneration resembling its association with Alzheimer’s disease. Hum Genet. 2015 Apr 19. PMID: 25893795 View abstract on Pubmed<\/a><\/p>\n\n\n\n

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Hallstrom KN, Srikanth CV, Agbor TA, Dumont CM, Peters K, Paraoan L<\/strong>, Casanova JE, Boll EJ, McCormick BA.<\/p>\n\n\n\n

PERP, a Host Tetraspanning Membrane Protein, is Required for Salmonella-Induced Inflammation. Cell Microbiol. 2014 Dec 9. PMID: 25486861 View abstract on Pubmed<\/a><\/p>\n\n\n\n

\n\n\n\n

Soriano-Roman\u00ed L, Garc\u00eda-Posadas L, L\u00f3pez-Garc\u00eda A, Paraoan L<\/strong>, Diebold Y. <\/p>\n\n\n\n

Thrombospondin-1 induces differential response in human corneal and conjunctival epithelial cells lines under in vitro inflammatory and apoptotic conditions. Exp Eye Res. 2015 May;134:1-14. doi: 10.1016\/j.exer.2015.03.004 View Abstract on Pubmed<\/a><\/p>\n\n\n\n

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Kay P, Yang YC, Hiscott P, Gray D, Maminishkis A, Paraoan L<\/strong>.<\/p>\n\n\n\n

Age-related changes of cystatin C expression and polarized secretion by retinal pigment epithelium: potential age-related macular degeneration links. Invest Ophthalmol Vis Sci. 2014 Feb 14. PMID: 24458156 View abstract on Pubmed<\/a><\/p>\n\n\n\n

\n\n\n\n

Kay P, Yang YC, Paraoan L<\/strong>.<\/p>\n\n\n\n

Directional protein secretion by the retinal pigment epithelium: roles in retinal health and the development of age-related macular degeneration. J Cell Mol Med. 2013 May 11. PMID: 23663427 View abstract on Pubmed<\/a><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n
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Davies L, Spiller D, White M R H, Grierson I, Paraoan L<\/strong>.<\/p>\n\n\n\n

PERP expression stabilizes active p53 via modulation of p53-MDM2 interaction in uveal melanoma cells. Cell Death and Disease 2011 Mar 31; 2:e136. PMID: 21451571 View abstract on Pubmed<\/a><\/p>\n\n\n\n

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O’Reilly S, Pollock N, Currie L, Paraoan L<\/strong>, Clark AF, Grierson I. <\/p>\n\n\n\n

Inducers of cross-linked actin networks in trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2011 Sep 21;52(10):7316-24. doi: 10.1167\/iovs.10-6692 View abstract on Pubmed<\/a><\/p>\n\n\n\n

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Paraoan L<\/strong>, Hiscott P, Gosden C, Grierson I.<\/p>\n\n\n\n

Cystatin C in macular and neuronal degenerations: Implications for mechanism(s) of Age-related Macular Degeneration. Vision Res. 2010 mar 31;50(7):737-742. PMID: 19917302 View abstract on Pubmed<\/a><\/p>\n\n\n\n

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Davies L, Gray D, Spiller D, White MRH, Damato B, Grierson I, Paraoan L<\/strong>.<\/p>\n\n\n\n

P53 apoptosis mediator PERP: localization, function and caspase activation in uveal melanoma. J Cell Mol Med. 2009 13;8B:1995-2007. PMID: 19040420 View abstract on Pubmed<\/a><\/p>\n\n\n\n

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Paraoan L<\/strong>, Gray D, Hiscott P, Garcia-Fianana M, Lane B, Damato B, Grierson I.<\/p>\n\n\n\n

Cathepsin S and its inhibitor Cystatin C: imbalance in uveal melanoma. Frontiers in Bioscience. 2009 Jan 1;14:2504-2513. PMID: 19273215 View abstract on Pubmed<\/a><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n
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Paraoan L<\/strong>, Gray D, Hiscott P, Ebrahimi B, Damato B, Grierson I.<\/p>\n\n\n\n

Expression of p53-induced apoptosis effector PERP in primary uveal melanomas: downregulation is associated with aggressive type. Exp Eye Res. 2006 Oct;83(4):911-9. PMID: 16784742 View Abstract on PubMed<\/a><\/p>\n\n\n\n

\n\n\n\n

Paraoan L<\/strong>, Grierson I.<\/p>\n\n\n\n

Focus on molecules: Cystatin C. Exp Eye Res. 2007 Jun;84(6):1019-20. PMID: 16626703 View Abstract on PubMed<\/a><\/p>\n\n\n\n

\n\n\n\n

Ratnayaka A, Paraoan L<\/strong>, Spiller DG, Hiscott P, Nelson G, White MR, Grierson I.<\/p>\n\n\n\n

A dual Golgi- and mitochondria-localised Ala25Ser precursor cystatin C: An additional tool for characterising intracellular mis-localisation leading to increased AMD susceptibility. Exp Eye Res. 2007 Jun;84(6):1135-9. PMID: 16635487 View Abstract on PubMed<\/a><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n
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Paraoan L<\/strong>, Grierson I, Maden BE.<\/p>\n\n\n\n

Fate of cystatin C lacking the leader sequence in RPE cells. Exp Eye Res. 2003 Jun;76(6):753-6. PMID: 12742358 View Abstract on PubMed<\/a><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n
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Paraoan L,<\/strong> Grierson I, Maden BE.<\/p>\n\n\n\n

Analysis of expressed sequence tags of retinal pigment epithelium: cystatin C is an abundant transcript. Int J Biochem Cell Biol. 2000 Apr;32(4):417-26. PMID: 10762067 View Abstract on PubMed<\/a><\/p>\n\n\n\n

\n\n\n\n

O’Reilly S, Pollock N, Currie L, Paraoan L<\/strong>, Clark AF, Grierson I.<\/p>\n\n\n\n

Inducers of cross-linked actin networks in trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2011 Sep 21;52(10):7316-24. PMID: 21849423 View Abstract on PubMed<\/a><\/p>\n\n\n\n

\n\n\n\n

Wade NC, Grierson I, O’Reilly S, Hoare MJ, Cracknell KP, Paraoan L<\/strong>, Brotchie D, Clark AF.<\/p>\n\n\n\n

Cross-linked actin networks (CLANs) in bovine trabecular meshwork cells. Exp Eye Res. 2009;89(5):648-659. PMID: 19540832 View abstract on Pubmed<\/a><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n
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Cryan LM, Paraoan L<\/strong>, Hiscott P, Damato B, Grierson I, Gray D, Farrell M, Doherty GA, Fitzgerald DJ, O’Brien C.<\/p>\n\n\n\n

Expression of COX-2 and prognostic outcome in uveal melanoma. Curr Eye Res. 2008 Mar 3;33:117-184. PMID: 18293189 View Abstract on Pubmed<\/a><\/p>\n\n\n\n

\n\n\n\n

Ratnayaka A, Paraoan L<\/strong>, Nelson G, Spiller DG, White MR, Hiscott P.<\/p>\n\n\n\n

Trafficking of osteonectin by retinal pigment epithelial cells: evidence for basolateral secretion. Int J Biochem Cell Biol. 2007;39(1):85-92. PMID: 17035068 View Abstract on PubMed<\/a><\/p>\n\n\n\n

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Hiscott P, Paraoan L<\/strong>, Choudhary A, Ordonez JL, Al-Khaier A, Armstrong DJ.<\/p>\n\n\n\n

Thrombospondin 1, thrombospondin 2 and the eye. Prog Retin Eye Res. 2006 Jan;25(1):1-18. PMID: 15996506 View Abstract on PubMed<\/a><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n
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Ordonez JL, Paraoan L<\/strong>, Hiscott P, Gray D, Garcia-Finana M, Grierson I, Damato B.<\/p>\n\n\n\n

Differential expression of angioregulatory matricellular proteins in posterior uveal melanoma. Melanoma Res. 2005 Dec;15(6):495-502. PMID: 16314734 View Abstract on PubMed<\/a><\/p>\n\n\n\n

\n\n\n\n

Paraoan L<\/strong>, Ratnayaka A, Spiller DG, Hiscott P, White MR, Grierson I.<\/p>\n\n\n\n

Unexpected intracellular localization of the AMD-associated cystatin C variant. Traffic. 2004 Nov;5(11):152-65. PMID: 15479453 View Abstract on PubMed<\/a><\/p>\n\n\n\n

\n\n\n\n

Hiscott P, Hagan S, Heathcote L, Sheridan CM, Groenewald CP, Grierson I, Wong D, Paraoan L<\/strong>.<\/p>\n\n\n\n

Pathobiology of epiretinal and subretinal membranes: Possible roles for the matricellular proteins thrombospondin 1 and osteonectin (SPARC). Eye. 2002 Jul;16(4):393-403. PMID: 12101446 View Abstract on PubMed<\/a><\/p>\n\n\n\n

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Paraoan L<\/strong>, White MR, Spiller DG, Grierson I, Maden BE.<\/p>\n\n\n\n

Precursor cystatin C in cultured retinal pigment epithelial cells: evidence for processing through the secretory pathway. Mol Membr Biol. 2001 Jul-Sep;18(3):229-36. PMID: 11681790 View Abstract on PubMed<\/a><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n
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Paraoan L<\/strong>, Grierson I, Maden BE.
Analysis of expressed sequence tags of retinal pigment epithelium: cystatin C is an abundant transcript.<\/a><\/p>\n\n\n\n

Int J Biochem Cell Biol.<\/em> 2000 32(4):417-26. doi: 10.1016\/s1357-2725(99)00143-0.Abstract on PubMed: https:\/\/pubmed.ncbi.nlm.nih.gov\/10762067\/<\/a> <\/p>\n","protected":false},"excerpt":{"rendered":"

Selected publications Aging retinal pigmented epithelium: omics-based insights into vision decline Matei IV and Paraoan L (2024) Aging (Albany NY) 16(12):10201-10202. doi: 10.18632\/aging.205914. Fucoxanthin diminishes oxidative stress damage in human placenta-derived mesenchymal stem cells through the PI3K\/Akt\/Nrf-2 pathway. Suwanmanee G, Tantrawatpan C, Kheolamai P, Paraoan L, Manochantr S. (2023) Sci Rep (Nature Publishing) 13(1):22974. doi: […]<\/p>\n","protected":false},"author":2059,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-72","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nPublications - Molecular Biology & Molecular Mechanisms of Disease<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.edgehill.ac.uk\/molecular-biology\/publications\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Publications - Molecular Biology & Molecular Mechanisms of Disease\" \/>\n<meta property=\"og:description\" content=\"Selected publications Aging retinal pigmented epithelium: omics-based insights into vision decline Matei IV and Paraoan L (2024) Aging (Albany NY) 16(12):10201-10202. doi: 10.18632\/aging.205914. Fucoxanthin diminishes oxidative stress damage in human placenta-derived mesenchymal stem cells through the PI3K\/Akt\/Nrf-2 pathway. Suwanmanee G, Tantrawatpan C, Kheolamai P, Paraoan L, Manochantr S. 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