Group: Molecular Biology and Mechanisms of Disease
Our research aims to further the understanding of fundamental molecular processes and pathways underlying physiology of various eye tissues in health, ageing and degeneration.
Studying gene expression and regulation in pigmented cells of the eye (retinal pigment epithelial, trabecular meshwork, uveal melanocytes) and focusing on fundamental cellular processes of proteolysis, apoptosis and cellular signalling, the group has identified and characterised key molecular determinants of normal and pathological states of specific eye tissues. The findings have relevance for major eye diseases (age-related macular degeneration, proliferative vitreoretinal disease, uveal melanoma and glaucoma) and wider implications for age-related degenerative processes, proliferative pathology and cancer. Through this we can support progress in their diagnosis and treatment.