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We are interested in understanding the physiology and pathophysiology of brain barriers and fluids. Normal functioning of brain barriers and fluids is vital for protection of the brain and maintaining homeostasis of the neuronal microenvironment. Often these defences are disrupted during neurological diseases such as stroke, Alzheimer’s disease, brain tumours and brain infections. Furthermore, emerging evidence also point to barrier disruption during peripheral diseases such as atrial fibrillation.

Blood brain barrier (BBB) image.
Blood-brain barrier (BBB) disruption (Patabendige & Janigro 2023)

To investigate the detailed cellular and molecular mechanisms of brain barriers and fluids, we have developed a range of advanced in vitro models that can reliably mimic the in vivo pathophysiology.

We are open to collaborations and sharing these model systems to better understand disease mechanisms.